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目的探讨2型糖尿病(T2DM)患者血脂代谢紊乱及胰岛素抵抗与脂肪肝发病的关系。方法对我院2003年住院的2型糖尿病患者,根据有无合并脂肪肝分为脂肪肝组和非脂肪肝组,进行空腹血胆固醇(TC)、甘油三酯(TG)、空腹胰岛素(FINS)、空腹血糖(FBG)、餐后2小时血糖(2h PBG)测定,进行HOMA-IR计算,并进行分析。结果合并脂肪肝组TG、FINS、LDL、HOMA-IR较无合并脂肪肝组升高(P均<0.05),而TC、FBG、PBG两组差别无显著性(P>0.05),HLD水平降低与脂肪肝呈负相关。结论2型糖尿病合并脂肪肝组血脂代谢紊乱、胰岛素抵抗更明显。
Objective To investigate the relationship between dyslipidemia and insulin resistance and the pathogenesis of fatty liver in type 2 diabetes mellitus (T2DM). Methods The type 2 diabetic patients hospitalized in our hospital in 2003 were divided into fatty liver group and non-fatty liver group according to the presence or absence of fatty liver, and fasting blood cholesterol (TC), triglyceride (TG), fasting insulin (FINS) , Fasting blood glucose (FBG) and 2-hour postprandial blood glucose (2h PBG), HOMA-IR was calculated and analyzed. Results The levels of TG, FINS, LDL and HOMA-IR in fatty liver group were significantly higher than those in non-steatohepatitis group (all P <0.05), but not in TC, FBG and PBG groups (P> 0.05) Negative correlation with fatty liver. Conclusion Type 2 diabetes mellitus patients with fatty liver dyslipidemia, insulin resistance is more obvious.