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作者曾以搞清楚熊果叶的药效为目的,对氯化苦诱发接触性皮炎(PC-CD)免疫性炎症的影响进行了讨论,发现其50％乙醇提取物具有治疗效果。熊果叶50％乙醇提取物与泼尼松龙并用时,能明显地提高泼尼松龙对预防和治疗PC-CD肿胀的效果,并分离出有效成分熊果甙。熊果甙对类固醇剂效果的增强作用,是仅对泼尼松龙所特有的作用,还是在PC-CD以外的Ⅳ型变态反应模型中也具有该作用,作者对此很感兴趣。Ⅳ型变态反应免疫性炎症模型采用PC-CD以及羊红血球迟发性过敏反应(SRBC-DTH),类固醇剂采用泼尼松龙和地塞米松,讨论熊果甙对免疫性炎症模型与类固醇
The authors discussed the effects of chloropicrin-induced contact dermatitis (PC-CD) on immune inflammation for the purpose of clarifying the efficacy of the bearberry leaf, and found that its 50% ethanol extract has a therapeutic effect. When combined with 50% ethanol extract and prednisolone, bearberry leaves can significantly improve the effect of prednisolone on the prevention and treatment of PC-CD swelling, and isolate the effective component bear fruit. The authors’ interest is that the effect of ursolic acid on steroids is only specific to prednisolone, and it also has this effect in models of type IV allergies other than PC-CD. Type IV allergic inflammatory model using PC-CD and erythrocyte delayed hypersensitivity (SRBC-DTH), steroids using prednisolone and dexamethasone to discuss the effects of ursolic acid on immune inflammation models and steroids