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目的了解外阴阴道假丝酵母菌病(VVC)及滴虫性阴道炎(TV)与阴道微生态情况的关系。方法用常规检测和细菌性阴道病(BV)三联法(BVset)测定2380例VVC(VVC组)、1399例TV患者(TV组)和648例正常体检者(对照组)阴道分泌物中过氧化氢(H2O2)浓度、唾液酸苷酶和白细胞酯酶活性。结果 VVC和TV患者三联法检测白细胞酯酶阳性率分别为34.7%和61.5%,明显高于对照组的6.6%(P<0.05);且TV组的白细胞酯酶阳性率显著高于VVC组(P<0.05)。结论 VVC和TV的发生与阴道微生态环境的失衡密切相关;对患者进行白带常规检测的同时进行BVset尤其是白细胞酯酶活性测定,能更好地反映出患者阴道微生态状况,对控制阴道炎的复发有一定的指导意义。
Objective To understand the relationship between vulvovaginal candidiasis (VVC) and trichomonas vaginitis (TV) and vaginal microflora. Methods Peripheral blood samples of 2380 patients with VVC (VVC group), 1399 patients with TV (TV group) and 648 healthy volunteers (control group) were assayed by routine test and BVstrans BV method. Hydrogen (H2O2) concentration, neuraminidase and leukocyte esterase activity. Results The positive rates of leukocyte esterase detected by triple assay in patients with VVC and TV were 34.7% and 61.5%, respectively, which were significantly higher than those in the control group (6.6%, P <0.05). The leukocyte esterase positive rate in TV group was significantly higher than that in VVC group P <0.05). Conclusion The occurrence of VVC and TV is closely related to the imbalance of vaginal microenvironment. The BVset, especially the leukocyte esterase activity, is measured routinely in patients with vaginal discharge, which can better reflect the vaginal microecological status of patients and control vaginitis The recurrence of a certain degree of guiding significance.