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为了评价磁共振成像(MRI)与99 Tcm-MDP骨显像对前列腺癌骨转移的诊断价值,计算机检索1990~2012年PubMed、EMBASE、EBSCO、Web of Knowledge、the Cochrane Library、Ovid等数据库,搜集关于MRI与99 TcmMDP骨显像诊断前列腺癌骨转移价值的试验,经过纳入标准和排除标准筛选后,根据QUADAS条目评估文献质量,然后提取数据和资料,采用Meta-Disc软件进行Meta分析,计算敏感性合并、特异性合并、诊断优势比合并(DOR合并),并绘制SROC曲线,计算曲线下面积(AUC)和Q*值。最终纳入5个研究,包括353个对象。Meta分析结果显示:MRI与99 Tcm-MDP骨显像诊断前列腺癌骨转移的敏感性合并分别为0.95(95%CI 0.90~0.98)与0.67(95%CI 0.58~0.75),特异性合并分别为0.97(95%CI 0.94~0.99)与0.88(95%CI 0.83~0.91),DOR合并分别为402.99(95%CI 119.05~1364.15)与23.85(95%CI 1.32~431.48);AUC与Q*分别为0.990 1、0.958 7和0.624 1、0.593 8。表明MRI诊断前列腺癌骨转移的效能优于99 Tcm-MDP骨显像。
To evaluate the diagnostic value of magnetic resonance imaging (MRI) and 99 Tcm-MDP bone scintigraphy on bone metastasis of prostate cancer, databases such as PubMed, EMBASE, EBSCO, Web of Knowledge, the Cochrane Library and Ovid from 1990 to 2012 were collected. The MRI and 99 TcmMDP Bone Imaging in the Diagnosis of Prostate Cancer Bone Metastasis, after inclusion criteria and exclusion criteria screening, the quality of the literature was assessed according to the QUADAS entry, then data and data were extracted and Meta-analysis was performed using Meta-Disc software to calculate sensitivity (AUC) and Q * values were calculated by plotting the SROC curves. Five studies were eventually enrolled, including 353 subjects. The results of Meta analysis showed that the sensitivity of MRI and 99 Tcm-MDP bone imaging in the diagnosis of prostate cancer bone metastasis were 0.95 (95% CI 0.90-0.98) and 0.67 (95% CI 0.58-0.75), respectively. The specific combinations were 0.97 (95% CI 0.94-0.99) and 0.88 (95% CI 0.83-0.91) respectively. The combined DOR were 402.99 (95% CI 119.05-1364.15) and 23.85 (95% CI 1.32-431.48), respectively; AUC and Q * were 0.990 1,0.958 7 and 0.624 1,0.593 8. MRI showed that bone metastases of prostate cancer were better than 99 Tcm-MDP bone scintigraphy.