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目的探讨脐血细胞因子与生后二年内婴儿反复喘息的相关性。方法抽取200例正常出生的足月新生儿脐血,排除生后出现呼吸窘迫综合症及病理性黄疸的新生儿标本8例,剩余192例脐血检测IL-2、IL-4、IL-6、IL-8、IL-10、IL-1β、IL-12、IL-17水平;新生儿通过电话或者门诊追踪随访观察二年,随访到172例,其中反复喘息婴儿(喘息次数大于等于2次)30例。将上述172例婴儿分为喘息组(30例)及对照组(142例),两组脐血细胞因子水平比较采用独立样本的T检验进行统计学分析。结果喘息组与非喘息组比较,IL-8有明显升高,差异有显著性(P<0.05)。而IL-2、IL-4、IL-6、IL-10、IL-1β、IL-12、IL-17细胞因子水平喘息组与非喘息组比较,差异无显著性(P>0.05)。结论 IL-8可成为生后二年婴幼儿反复喘息的预测因子。
Objective To investigate the correlation between umbilical cord blood cytokines and recurrent wheezing in infants within two years after birth. Methods Totally 200 neonates with full-term newborns were enrolled in this study. Eight neonates with post-natal respiratory distress syndrome and pathological jaundice were excluded. The remaining 192 cases of cord blood were assayed for IL-2, IL-4 and IL-6 IL-8, IL-10, IL-1β, IL-12 and IL-17 levels were detected in all newborns. The newborns were followed up for two years by telephone or outpatient follow-up and followed up to 172 cases, wheezing and wheezing repeatedly ) 30 cases. The 172 infants were divided into asthmatic group (n = 30) and control group (n = 142). The levels of umbilical cord blood cytokines in two groups were statistically analyzed by T-test with independent samples. Results Compared with non-wheezing group, wheezing group had significantly higher IL-8, the difference was significant (P <0.05). There was no significant difference between the asthmatic group and the non-asthmatic group on the levels of IL-2, IL-4, IL-6, IL-10, IL-1β, IL-12 and IL-17 (P> 0.05). Conclusion IL-8 can be a predictor of recurrent wheezing in infants and children two years after birth.