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目的探讨热休克蛋白70(HSP70)在合并C型人格特征抑郁HBV相关性肝癌患者中的表达情况及其临床意义。方法选择60例行肝切除术的HBV相关性肝癌患者分为A组(C型人格特征抑郁)及B组(无C型人格特征抑郁),每组各30例。检测HSP70在患者肿瘤组织及血液中的表达,并比较两组患者肿瘤的复发情况及无病生存率,同时分析影响C型人格特征抑郁HBV相关性HCC患者预后的因素。结果 A组患者肿瘤组织HSP70 mRNA及蛋白的表达均高于B组(P<0.05);A组患者6个月、12个月及18个月无病生存率低于B组(P<0.05);HSP70 mRNA>3.726是C型人格特征抑郁HBV相关性肝癌患者无病生存期的影响因素(P<0.05)。结论具有C型人格特征抑郁的HBV相关性肝癌患者肝切除术后的预后较差,可能与HSP70高表达有关;HSP70可能可作为预测肝癌患者术后早期复发的生物学标志物。
Objective To investigate the expression and clinical significance of heat shock protein 70 (HSP70) in patients with HBV-associated HCC complicated by C-type personality depression. Methods Sixty patients with HBV-related hepatocellular carcinoma undergoing hepatectomy were divided into group A (depression of C-type personality) and group B (depression without C-type personality), 30 cases in each group. The expression of HSP70 in the tumor tissue and blood of the patients was detected. The recurrence and disease-free survival rate of the two groups were compared. At the same time, the factors influencing the prognosis of the HBV-associated HCC patients with C-type personality depression were analyzed. Results The expression of HSP70 mRNA and protein in tumor tissue of group A were higher than that of group B (P <0.05). The disease-free survival rate of group A at 6, 12 and 18 months was lower than that of group B (P <0.05) ; HSP70 mRNA> 3.726 was the influencing factor of disease-free survival in patients with C-type personality depression and HBV-related hepatocellular carcinoma (P <0.05). Conclusion The prognosis of patients with HBV-related HCC who have depression of C-type personality is poor after liver resection, which may be related to the high expression of HSP70. HSP70 may be used as a biomarker to predict the early postoperative recurrence of HCC.