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采用人外周血淋巴细胞体外培养胞浆阻滞微核测试法,观察用3H-TdRβ线和60Coγ线照射引起的剂量-效应关系,并计算了3H,TdRβ线的相对生物效应值。3H-TdRβ线内照射和60COγ线外照射的剂量效应关系均符合Y=A+BX2=CX2线性-平方数学模式,淋巴细胞微核频率随β线和γ线剂量的增加而增加。3H-TdRβ线的RBE均值为1.19,表明其β线产生的生物效应是γ线的1.19倍。
The effect of 3H-TdRβ irradiation and 60Coγ irradiation irradiation on the dose-response relationship was observed by using the method of human peripheral blood lymphocyte culture in vitro. The relative biological effects of 3H and TdRβ were calculated. The dose-response relationship between 3H-TdRβ-IR and 60COγ-IR was in line with the Y-A + BX2 = CX2 linear-squared mathematical model, and the frequencies of lymphocyte micronuclei increased with the increase of β-ray and γ-ray dose. The mean RBE for the 3H-TdRβ line was 1.19, indicating a bioeffect of 1.19 times the γ-ray for its β-line.