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目的:通过研究白细胞介素-6(IL-6)在支气管哮喘发作并肺炎支原体(MP)感染患儿血清中的表达水平阐明支原体感染与哮喘发作的关系。方法:收集2009年2月～2010年8月支气管哮喘发作并MP感染患儿48例、非MP感染支气管哮喘发作患儿45例,采用ELISA方法检测两组外周血IL-6水平。结果:外周血IL-6水平在支气管哮喘并MP感染发作组(13.86±12.46 pg/mL)明显高于非MP感染支气管哮喘发作组(7.94±8.51 pg/mL),P<0.05。结论:支气管哮喘发作并MP感染患儿外周血IL-6水平明显高于非MP感染支气管哮喘发作患儿,表明MP感染在支气管哮喘发作过程中起重要作用。
OBJECTIVE: To elucidate the relationship between mycoplasma infection and asthma attacks by studying the expression of interleukin-6 (IL-6) in serum of children with bronchial asthma and mycoplasma pneumoniae (MP) infection. Methods: Forty-eight children with bronchial asthma and MP infection were collected from February 2009 to August 2010 and 45 children with non-MP infection bronchial asthma. The levels of IL-6 in peripheral blood were detected by ELISA. Results: The level of IL-6 in peripheral blood was significantly higher in patients with bronchial asthma and MP infection (13.86 ± 12.46 pg / mL) than those without bronchial asthma (7.94 ± 8.51 pg / mL), P <0.05. Conclusion: The level of IL-6 in peripheral blood of children with bronchial asthma attack and MP infection is significantly higher than that of children without bronchial asthma attack, indicating that MP infection plays an important role in the pathogenesis of bronchial asthma.