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作者报告沙土鼠大脑实验性缺血后,用DOPS (L—苏糖—3,4—二羟基苯丝氨酸)处理后,海马CAI神经元生长因子受体(NGFR)的免疫反应性降低,对损伤的脑细胞起到保护作用。 材料与方法:蒙古雄性沙土鼠(9—11周龄,体重60—70g),实验组:(1)载体组(n=7),0.5％甲基纤维素腹腔注射。(2)苄丝肼+DOPS组,先给苄丝肼(10mg/kg)30分钟后再给DOPS,前者可阻断DOPS在鼠脑内转变成去甲肾上腺素(NE)。DOPS剂量为30、100、300mg/kg用0.5％甲基纤维素混息(每种剂型n=9—10,(3)苄丝肼+载体组(n=
The authors report that the immunoreactivity of hippocampal CAI neuronal growth factor receptor (NGFR) decreased after treatment with DOPS (L-threose-3,4-dihydroxyphenylserine) after experimental cerebral ischemia in gerbils, Brain cells play a protective role. MATERIALS AND METHODS: Mongolian male gerbils (9-11 weeks old, body weight 60-70g) were included in the experimental group: (1) vehicle group (n = 7) and 0.5% methylcellulose by intraperitoneal injection. (2) Besserazine + DOPS group, DOPS was given to benidrazide (10mg / kg) for 30 minutes and then to DOPS, the former could block the conversion of DOPS to norepinephrine (NE) in rat brain. DOPS doses of 30, 100, 300 mg / kg were mixed with 0.5% methylcellulose (n = 9-10 for each dosage form, (3) benserazide + vehicle group (n =