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目的:探讨参麦注射液对急性心肌梗死患者血清内皮素水平及心室重构的影响。方法:急性心肌梗死患者40例分为参麦治疗组及常规治疗组各20例,观察2组患者血中内皮素水平变化;应用心脏彩超测量2组左心室舒张末期内径、收缩及舒张末期容积、左室射血分数及短轴缩短率。并与同期健康体检正常者(对照组)进行对比分析。结果:治疗后4,7 d参麦治疗组血中内皮素水平与常规治疗组比较差异有统计学意义(P<0.05);治疗后4周常规治疗组左心室舒张末期内径,收缩、舒张末期容积与本组治疗后1周及同期参麦治疗组比较,差异均有统计学意义(P<0.05);参麦治疗组左室射血分数和短轴缩短率与本组治疗后1周及同期常规治疗组比较差异有统计学意义(P<0.05)。结论:参麦注射液可降低急性心肌梗死患者血中内皮素水平,抑制或减轻急性心肌梗死后心室重构的发生、发展,改善左心室功能及预后。
Objective: To investigate the effect of Shenmai injection on serum endothelin level and ventricular remodeling in patients with acute myocardial infarction. Methods: Forty patients with acute myocardial infarction were divided into two groups: 20 cases in each group and 20 cases in conventional treatment group respectively. The levels of endothelin in the two groups were observed. The left ventricular end-diastolic diameter, systolic and diastolic volume , Left ventricular ejection fraction and short axis shortening rate. And with the same period of normal physical examination (control group) for comparative analysis. Results: At 4 and 7 days after treatment, the level of endothelin in the serum of the Shenmai treatment group was significantly different from that of the conventional treatment group (P <0.05). After 4 weeks of treatment, the left ventricular end-diastolic diameter, systolic and diastolic end- Volume and the group 1 week after treatment and the same period of treatment of Shenmai treatment group, the difference was statistically significant (P <0.05); Shenmai treatment group, left ventricular ejection fraction and short axis shortening after 1 week of treatment and this group and Compared with the conventional treatment group, the difference was statistically significant (P <0.05). Conclusion: Shenmai injection can reduce the level of endothelin in the blood of patients with acute myocardial infarction, inhibit or reduce the incidence of ventricular remodeling, development and improvement of left ventricular function and prognosis after acute myocardial infarction.