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[目的]观察润明颗粒联合人工泪液治疗围绝经期干眼疗效。[方法]使用随机平行对照方法,将50例门诊患者按就诊顺序号方法简单随机分两组。对照组50例羧甲基纤维素钠滴眼液,1滴/次,4次/d,点患眼。治疗组50例润明颗粒(淫羊藿,仙茅,巴戟肉,当归,黄柏,知母,半夏,麦冬,人参,甘草等),1袋/次,3次/d,口服;羧甲基纤维素钠滴眼液治疗同对照组。连续治疗1个月为1疗程。观测临床症状、干眼相关症状积分、泪液分泌试验(SchirmerⅠ)、泪膜破裂时间(BUT)、角膜荧光素染色、SRI、SAI、不良反应。治疗1疗程,随访3个月,判定疗效。[结果]干眼相关症状积分、泪液分泌试验(SchirmerⅠ)、泪膜破裂时间(BUT)、角膜荧光素染色、SRI、SAI治疗组优于对照组(P<0.01,P<0.05)。[结论]润明颗粒联合人工泪液治疗围绝经期干眼,疗效满意,无严重不良反应,值得推广。
[Objective] To observe the effect of Runming Granule combined with artificial tears in treating perimenopausal dry eye. [Methods] Using randomized parallel control method, 50 outpatients were randomly divided into two groups according to the sequence number of visiting doctor. Control group, 50 cases of sodium carboxymethyl cellulose eye drops, 1 drop / time, 4 times / d, the point of eye. The treatment group, 50 cases of Runming granules (Epimedium, Curculigosidea, Morinda officinalis, Angelica, Treats, Anemarrhenae, Pinellia, Ophiopogon, ginseng, licorice, etc.), 1 bag / time, 3 times / d, Sodium carboxymethyl cellulose eye drops treatment with the control group. Continuous treatment for 1 month for a course of treatment. Clinical symptoms, dry eye-related symptom scores, Schirmer I, tear film break-up time (BUT), corneal fluorescein staining, SRI, SAI and adverse reactions were observed. Treatment of a course of treatment, followed up for 3 months to determine the efficacy. [Results] The scores of dry eye related symptoms, Schirmer I, BUT, corneal fluorescein staining, SRI and SAI were superior to those of the control group (P <0.01, P <0.05). [Conclusion] Runming granules combined with artificial tears in the treatment of perimenopausal dry eye, satisfactory results, no serious adverse reactions, it is worth promoting.