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优降糖是治疗非胰岛素依赖型糖尿病(NID-DM)常用的口服降糖药。为了探讨食物是否影响优降糖的吸收,给药时间和剂量对血药浓度有何影响,我们对9例 NIDDM 患者进行了不同服药方法的自身对照研究。患者入院后随机采用下述优降糖治疗:Ⅰ组(5例):①顿服法:每日早餐前30′顿服5mg×7天;②早餐法;每日进早餐中顿服5mg×7天;③分服法:每日早、午餐前30′各服2.5mg×7天。Ⅱ组(4例):服药次序为(3)—(2)—(1)。于服药第1日、第2周和第3周末分别在早上服药前,服药后1,2,3,4,6,12,24小时抽血。血浆优降糖浓度采用高压液相色谱测定。
Glyburide is a commonly used oral hypoglycemic agent for the treatment of non-insulin-dependent diabetes mellitus (NID-DM). In order to investigate whether food affects the absorption of glyburide, the timing of administration, and the effect of dosage on plasma concentrations, we conducted a self-controlled study of nine medications in patients with NIDDM. Patients admitted to hospital after randomized to the following glyburide therapy: Ⅰ group (5 cases): ① Dayton method: daily breakfast before 30 ’Dayton served 5mg × 7 days; ② breakfast; daily breakfast in Dayton clothing 5mg × 7 days; ③ service method: daily morning, lunch 30 ’each serving 2.5mg × 7 days. Group Ⅱ (4 cases): taking the order of (3) - (2) - (1). In the first day of medication, the first two weeks and the third weekend before taking the drug in the morning, taking 1,2,3,4,6,12,24 hours after taking blood. Plasma glyburide concentrations were measured by high pressure liquid chromatography.