论文部分内容阅读
近年来证明,气道吸入某些合成的糖皮质类固醇能有效地治疗儿童哮喘。在欧洲,是以二丙酸氯地米松(BDP)和丁地去炎松(BUD)为代表。这些皮质激素在临床疗效方面并无重大差异。从可能发生的全身性副作用考虑,BUD 因其清除迅速且半衰期短更适合于儿童。对于年小的儿童,一般使用干粉制剂代替常规气雾剂吸入,因为它更易于掌握,但哮喘较为严重者采用后一方法较为有利,不过两者的差别并不明显。近来,高浓度的 BUD 混悬制剂已经问世,有人报道利用喷雾器经面罩吸入 BUD 1ml(1mg)bid,治疗1例(年龄19个月)对类固醇有依赖性的严重哮喘患儿取得显著疗效。吸入皮质类固醇常并用β激动剂。在皮质类固醇吸入之前10～15分钟先给予支气管扩张气雾剂,能否由于它使药物深达肺内气道,从而加强后者的效果,在儿童中尚未进行过研究,但这在成人中已得到证实.一般给予 BDP(或 BUD)100～600μg/d 就可
In recent years, airway inhalation of certain synthetic glucocorticosteroids can effectively treat childhood asthma. In Europe, it is represented by beclomethasone dipropionate (BDP) and triamcinolone acetonide (BUD). There is no significant difference in the clinical efficacy of these corticosteroids. In view of the possible systemic side effects, BUD is more suitable for children because of its rapid clearance and short half-life. For young children, dry powder formulations are generally used instead of conventional aerosol inhalation because it is easier to master, but the more severe asthma is more advantageous with the latter method, although the difference is not obvious. Recently, high concentrations of BUD suspension preparations have been reported. It has been reported that inhalation of BUD 1 ml (1 mg) bid via a mask through a mask achieves a significant effect in treating 1 steroid-dependent severe asthma in children (age 19 months). Inhaled corticosteroids often with beta agonist. Bronchodilator aerosols given 10 to 15 minutes before inhalation of corticosteroids enhance the effects of the latter because of the drug’s ability to reach the lungs’ airways, which has not been studied in children, but in adults Has been confirmed.Generally given BDP (or BUD) 100 ~ 600μg / d can be