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许多病的患者血清具有冷反应淋巴细胞毒性,如:系统性红斑狼疮(SLE)、多发性硬化、病毒和寄生虫感染、以及自身免疫性甲状腺疾病等。其中以SLE患者血清的冷反应淋巴细胞毒性研究的最为广泛。在自身免疫性甲状腺疾病中,关于该淋巴细胞毒素的性质,特异性和功能方面的研究报道甚少。由于该毒素可能对自身免疫反应起调节作用,故本文意在进一步阐明桥本氏甲状腺炎和Graves病患者血清中的冷反应淋巴细胞毒活性(LC-TA)。
Many patients have cold-reactive lymphocyte sera, such as systemic lupus erythematosus (SLE), multiple sclerosis, viral and parasitic infections, and autoimmune thyroid diseases. Among them, the cold reaction of SLE patients is the most extensively studied lymphocytotoxicity. In the autoimmune thyroid disease, few reports on the nature, specificity and function of this lymphocytic toxin have been reported. Since the toxin may have a regulatory effect on the autoimmune response, this article is intended to further elucidate the cold reactive lymphocyte cytotoxicity (LC-TA) in sera of Hashimoto’s thyroiditis and Graves disease.