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甘油作为制剂学上的溶剂,在临床上有极其广泛的用途,但作为治疗用药,至今仍受到很大限制。因口服甘油极易产生恶心呕吐,病人不愿接受,而配制注射液又无相应的注射用原料。静注或静滴甘油注射液用于降低眼压和颅内压治疗青光眼及脑水肿,特别对缺血性脑血管疾病如脑梗塞性脑水肿和这类危重病人的抢救成活率较常用的甘露醇,山梨醇等脱水剂更好。其优点是:①甘油粘度大,吸水性和渗透能力较强,②减轻脑水肿的效果更持久,③在体内可作为能源被代谢,④能促
Glycerol, as a formulation solvent, has a very wide range of clinical uses, but as a therapeutic drug, it still has a lot of restrictions. Due to oral glycerin easily produce nausea and vomiting, the patient did not want to accept, and the preparation of injection and no corresponding injection of raw materials. Intravenous or intravenous injection of glycerol for the reduction of intraocular pressure and intracranial pressure in the treatment of glaucoma and brain edema, especially for ischemic cerebrovascular diseases such as cerebral infarction cerebral edema and rescue survival of such critically ill patients than the commonly used mannitol Alcohol, sorbitol and other dehydrating agent better. Its advantages are: ① glycerine viscosity, strong water absorption and permeability, ② reduce the effect of cerebral edema more durable, ③ can be used as an energy metabolism in the body, ④ can promote