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从猫第四脑室给药。毒扁豆碱降压作用可被阿托品及育亨宾阻断;可乐定降压作用可被育亨宾、密胆碱及阿托品阻断,不被可卡因阻断,破坏中枢去甲肾上腺素能末梢后,阿托品的阻断作用消失;可乐定减少脑室灌流液Ach释出量。提示猫延髓胆碱能和去甲肾上腺素能神经在心血管调节功能上相互影响,它们似有可能同在一心血管神经原形成突触联系共同对血压行抑制性调节;可乐定可能通过激动通路上突触后α_2受体产生降压作用。
From cat fourth ventricle. The hypotensive effects of physostigmine can be blocked by atropine and yohimbine; the clonidine blood pressure can be blocked by yohimbine, achicoline and atropine, not blocked by cocaine, which can damage the central noradrenergic terminals , The disappearance of atropine blockade; clonidine reduce intraventricular perfusion fluid Ach release. Suggesting that the cat’s medulla cholinergic and noradrenergic nerves interact with each other on cardiovascular regulation, and that they appear likely to form synaptic connections with a cardiovascular neuron to suppress inhibitory regulation of blood pressure; clonidine may be activated through an inflammatory pathway Post-synaptic α_2 receptor produces antihypertensive effect.