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目的分析比较比索洛尔和卡维地洛治疗慢性心力衰竭的疗效。方法将2007年1月至2008年1月收治的78例慢性心力衰竭患者随机分为比索洛尔组40例和卡维地洛组38例,比索洛尔组在继续常规抗治疗的基础上,给予口服比索洛尔治疗;卡维地洛组在继续常规抗治疗的基础上,给予口服卡维地洛治疗。所有患者治疗前后均行超声心动图检查,测量LVEF和左心室舒张末期容积(LV-EDV)、左心室收缩末期容积(LVESV),测量血压和心率。治疗一年后,比较两组患者各项指标。结果索洛尔组和卡维地洛组治疗前后超声心动图指标LVEDV、LVESV、LVEF、血压、收缩压和舒张压均具有显著性差异(P<0.01);而治疗后两组组间比较只有LVEF比较有显著性差异(P<0.05),其余各项指标均不存在显著性差异(P>0.05),差异无统计学意义。结论应用比索洛尔和卡维地洛治疗慢性心力衰竭患者,疗效相似,均能显著改善心力衰竭患者的心功能,临床可以推广应用。
Objective To analyze and compare the efficacy of bisoprolol and carvedilol in the treatment of chronic heart failure. Methods Seventy-eight patients with chronic heart failure who were admitted to our hospital from January 2007 to January 2008 were randomly divided into bisoprolol group (40 cases) and carvedilol group (38 cases). On the basis of continuing anti-tuberculosis treatment, Given oral bisoprolol treatment; carvedilol group continued conventional anti-treatment on the basis of given oral carvedilol treatment. All patients underwent echocardiography before and after treatment. LVEF and LV-EDV, LVESV were measured and blood pressure and heart rate were measured. After one year of treatment, the two groups of patients were compared. Results Before and after treatment, the indexes of LVEDV, LVESV, LVEF, blood pressure, systolic pressure and diastolic pressure were significantly different between the two groups (P <0.01) LVEF was significantly different (P <0.05), the rest of the indicators were not significantly different (P> 0.05), the difference was not statistically significant. Conclusion The application of bisoprolol and carvedilol in patients with chronic heart failure, similar efficacy, can significantly improve heart failure patients with cardiac function, clinical application can be promoted.