论文部分内容阅读
本实验用家兔复制内毒素性发热模型,观察电针退热时血浆,CSF中PGE_2含量的变化。实验结果表明:在发热高峰期,两组动物的血浆、CSF中PGE_2含量都比发热前明显升高(P<0.091)。电针对内毒素性发热有明显地抑制作用。电针组动物的血浆及CSF中PGE_2含量明显低于对照组(P<0.001)。作者推论:PGE_2是内毒素性发热的一种中枢性发热介质,电针的退热作用可能是通过一种未知方式抑制中枢PGE_2的产生或释放而实现的。
In this study, rabbits were used to replicate endotoxin fever model to observe the changes of PGE 2 content in plasma and CSF when EA was withdrawn. The experimental results showed that at the peak of fever, the content of PGE_2 in plasma and CSF of both groups were significantly higher than those before fever (P <0.091). Electroacupuncture significantly inhibited endotoxin fever. The content of PGE_2 in plasma and CSF of EA group was significantly lower than that of control group (P <0.001). The authors concluded that PGE 2 is a central mediator of endotoxin fever and that the antipyretic effect of electroacupuncture may be mediated by an unknown manner that inhibits the production or release of central PGE 2.