晚期胃癌介入化学疗法的临床疗效研究

来源 :华西医学 | 被引量 : 0次 | 上传用户:define_misser
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目的观察介入化学疗法(化疗)治疗晚期胃癌的临床疗效。方法对2013年1月-12月30例晚期胃癌患者行动脉内灌注化疗及栓塞治疗,3周治疗1次,3次治疗后评估疗效,临床疗效以症状改善情况来评价,包括腹痛、食欲差、恶心、呕吐及大便潜血的缓解。肿瘤病灶的大小行腹部CT检查进行评估。结果 30例患者中,28例腹痛患者缓解19例(67.9%),24例纳差患者食欲改善18例(75.0%),16例呕吐患者缓解15例(93.8%),12例粪便潜血阳性患者转阴9例(75.0%)。总有效率为83.3%,其中8例介入治疗后接受手术治疗。随访6、12、24个月的生存率分别是85.0%、65.0%、25.0%。结论晚期胃癌介入灌注化疗及肝脏转移灶栓塞可有效改善患者症状,降级降低肿瘤分期,部分患者争取到二期手术机会,是治疗晚期胃癌的有效方法。 Objective To observe the clinical efficacy of interventional chemotherapy (chemotherapy) in the treatment of advanced gastric cancer. Methods Thirty patients with advanced gastric cancer from January 2013 to December 2013 underwent intra-arterial infusion chemotherapy and embolization, once a week for 3 weeks. The curative effect was evaluated after 3 times of treatment. The clinical efficacy was evaluated by the improvement of symptoms including abdominal pain, poor appetite , Nausea, vomiting and fecal occult blood remission. The size of the tumor lesion was assessed by abdominal CT examination. Results Among 30 patients, 19 (67.9%) were relieved in 28 patients with abdominal pain, 18 patients (75.0%) were improved in 24 patients with anorexia, 15 (93.8%) were relieved in 16 patients with vomiting, 12 were positive in fecal occult blood Negative in 9 cases (75.0%). The total effective rate was 83.3%, of which 8 patients underwent surgery after interventional therapy. The survival rates at 6, 12 and 24 months after follow-up were 85.0%, 65.0% and 25.0% respectively. Conclusion The interventional chemotherapy of advanced gastric cancer and hepatic metastasis can effectively improve the symptoms of patients with advanced gastric cancer. Degrading can reduce the staging of tumor. Some patients get the chance of second stage operation, which is an effective method for the treatment of advanced gastric cancer.
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