头孢卡品酯是第四代头孢类抗菌素的重要品种,人们已经对以去乙酰基-7-氨基头孢烷酸(D-7ACA)为起始原料合成头孢卡品酯的工作进行了大量研究,其中大部分都涉及到D-7ACA上羧基的保护,因此,对D-7ACA的羧基保护的研究是非常重要的.以二苯基重氮甲烷和D-7ACA为起始原料,采用超声波辅助的方法,以70%的收率合成了去乙酰基-7-氨基头孢烷酸二苯甲酯. Ceftazidime is the fourth generation of cephalosporins an important species of antibiotics, people have to deacetyl-7-aminocephalosporanic acid (D-7ACA) as the starting material for the synthesis of cephalosporins work done a lot of research, Most of them involve the protection of the carboxyl groups on D-7ACA, therefore, the study on the protection of the carboxyl group of D-7ACA is very important.Using the diphenyldiazomethane and D-7ACA as the starting materials, Method, diphenylmethyl desacetyl-7-aminocephalosporanic acid was synthesized in 70% yield.