目的为研究洛赛克（Ｌｏｓｅｃ）在Ｈ２受体拮抗剂治疗无效的老年人返流性食管炎治疗中的效果。方法经内镜检查确诊的返流性食管炎３７例（根据ＳａｖａｒｙＭｉｌｅｒ分级，２度２８例，３度９例）其中有食管裂孔疝８例，胃次全手术史７例，男２６例，女１１例，年龄５７７２岁，服用Ｌｏｓｅｃ２０ｍｇ，每日二次，结果正规治疗６周后，根据临床症状缓解消失情况和内镜复查的结果，总有率９４５９％（３５／３７）。结论治疗结果表明Ｌｏｓｅｃ治疗Ｈ２受体拮抗剂治疗无效的中重度返流性食管炎仍可取得很好效果，疗效可靠，副反应少而轻微，但用药剂量不能太小，因返流性食管炎复发率极高，尤其是老年人，应较长时间的维持治疗 Objective To investigate the efficacy of Losec in the treatment of reflux esophagitis in elderly patients with an inactive H2 receptor antagonist. Methods Thirty-seven cases of reflux esophagitis confirmed by endoscopy (according to Savary-Miller classification, 2 degrees 28 cases and 3 degrees 9 cases), including 8 cases of esophageal hiatal hernia, 7 cases of complete gastrectomy and 26 cases of male Cases, female 11 cases, aged 5772 years, taking Losec20mg, twice daily, the results of formal treatment for 6 weeks, according to the clinical symptoms and disappearance of endoscopy and endoscopic findings, the total rate of 9459% (35 / 37). Conclusion The results show that Losec treatment of H2 receptor antagonist treatment of moderate to moderate reflux esophagitis can still get good results, reliable, minor and minor side effects, but the dose should not be too small, due to reflux esophagitis Recurrence rate is extremely high, especially in the elderly, maintenance treatment should be a long time