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目的研究新生儿缺氧缺血性脑病（HIE）血清一氧化氮（NO）的变化及其临床意义。方法采用镀铜镐还原法和放射免疫法检测48例HIE患者血清NO2／NO3和cGMP的含量。结果新生儿HIE血清中NO2／NO3和cGMP的含量明显高于对照组（P＜0．01），治疗后患者血清中NO2／NO3和cGMP的含量较治疗前明显减低（P＜0．05）。结论NO参与了新生儿HIE的发病过程，检测血清NO的含量有助于判断患者的病情。提示临床开发和应用NO生成抑制剂可能有助于新生HIE的治疗。
Objective To study the changes of serum nitric oxide (NO) in neonates with hypoxic-ischemic encephalopathy (HIE) and its clinical significance. Methods The serum levels of NO2 / NO3 and cGMP in 48 HIE patients were detected by copper-plated hoop reduction and radioimmunoassay. Results The levels of NO2 / NO3 and cGMP in neonatal HIE serum were significantly higher than those in the control group (P <0.01). After treatment, the levels of NO2 / NO3 and cGMP in the serum were significantly decreased (P <0.05) . Conclusion NO participates in the pathogenesis of neonatal HIE. Detecting the content of serum NO helps to judge the patient’s condition. Suggesting that clinical development and application of NO production inhibitors may contribute to the treatment of neonatal HIE.