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目的探讨肾移植术后发生肾功能恢复延迟(DGF)的危险因素。方法对肾移植术后发生DGF的111例患者(DGF组)及同期未发生DGF的141例患者(对照组)的临床资料进行回顾性分析,用χ2检验进行单因素分析,用Logistic进行多因素回归分析,计算其相对危险度。结果单因素及多因素分析表明,冷缺血时间,热缺血时间,术中、术后早期低血压,群体反应性抗体阳性,急性肾小管坏死,加速性排斥反应,神经钙调素抑制剂肾毒性,术后早期尿漏、输尿管梗阻等8种因素是发生DGF的危险因素。结论术前、术中及术后早期的多种因素均能导致DGF,其发生基础为缺血-再灌注损伤,应针对多种危险因素采取综合预防措施。
Objective To investigate the risk factors of delayed renal function recovery (DGF) after renal transplantation. Methods The clinical data of 111 patients with DGF (DGF group) and 141 patients without DGF (Control group) after renal transplantation were retrospectively analyzed. One-factor analysis was performed using χ2 test and multivariate Logistic Regression analysis, calculate the relative risk. Results Univariate and multivariate analysis showed that cold ischemia, warm ischemia, intraoperative and postoperative early hypotension, positive group antibody, acute tubular necrosis, accelerated rejection, neurotrophic hormone inhibitor Nephrotoxicity, early postoperative urinary leakage, ureteral obstruction and other eight kinds of factors are risk factors for the occurrence of DGF. Conclusions There are many kinds of factors that can lead to DGF preoperatively, intraoperatively and early postoperatively. The underlying causes are ischemia - reperfusion injury. Comprehensive preventive measures should be taken according to various risk factors.