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各种靶组织的胰岛素抵抗和胰腺 β细胞分泌功能受损是导致 2型糖尿病的主要原因〔1〕,但机制不明 ;为探讨 2型糖尿病胰岛素抵抗的分子机制 ,以一种自发发病的 2型糖尿病模型—OLETF大鼠为对象 ,研究其肝脏、骨胳肌、脂肪组织内胰岛素信号传导分子胰岛素受体底物 1(IRS
Various target tissues of insulin resistance and impaired pancreatic β-cell secretion is the leading cause of type 2 diabetes [1], but the mechanism is unknown; in order to explore the molecular mechanism of type 2 diabetes insulin resistance, a spontaneous type 2 Diabetes mellitus (OLETF) model was used to study the changes of insulin signaling molecule insulin receptor substrate 1 (IRS) in liver, skeletal muscle and adipose tissue