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目的:观察无创正压通气和纳络酮联用于煤工尘肺合并呼吸衰竭患者的临床疗效。方法:71例煤工尘肺合并呼吸衰竭患者随机分为:甲组(传统常规综合治疗)、乙组(在甲组基础上加无创通气治疗)、丙组(在乙组基础上加纳络酮治疗),观察3组患者治疗前后pH、PaO2、PaCO2的变化。结果:治疗前3组的pH、PaO2、PaCO2无统计意义;治疗后3组的pH、PaO2、PaCO2与治疗前相比较差异有统计意义(P<0.05);乙组、丙组治疗后同一时间内的pH、PaO2、PaCO2与甲组相比较差异有统计意义(P<0.05);同一时间内丙组与乙组的pH、PaO2、PaCO2比较差异有统计意义(P<0.05)。结论:无创正压通气联用纳络酮治疗煤工尘肺合并呼吸衰竭比单用无创正压通气治疗效果更好,并且临床操作方便、安全,值得推广应用。
Objective: To observe the clinical effect of noninvasive positive pressure ventilation and naloxone in patients with pneumoconiosis complicated with respiratory failure. Methods: A total of 71 patients with coal pneumoconiosis and respiratory failure were randomly divided into two groups: group A (conventional conventional combined therapy), group B (noninvasive ventilation based on group A), group C (based on group B plus naloxone treatment ). The changes of pH, PaO2 and PaCO2 before and after treatment in 3 groups were observed. Results: The pH, PaO2 and PaCO2 in the three groups before treatment were not statistically significant. The pH, PaO2 and PaCO2 in the three groups after treatment were significantly different from those before treatment (P <0.05) There were significant differences in pH, PaO2 and PaCO2 between group A and group B (P <0.05). There was significant difference between group C and group B in pH, PaO2 and PaCO2 at the same time (P <0.05). Conclusion: Noninvasive positive pressure ventilation combined with naloxone is more effective than single noninvasive positive pressure ventilation in the treatment of coal worker pneumoconiosis complicated with respiratory failure. The clinical operation is convenient and safe and should be popularized and applied.