本文综述了引起硬皮病的各种可能内、外因素。前者有副蛋白沉积、糖尿病等,后者包括接触硅、氯化乙烯及某些药物(争光霉素、青霉胺、镇痛新及维生素K)。描述了乳房整形后出现的硬皮病、色氨酸诱发的嗜酸性肌痛综合征、中毒性油综合征及螺旋体感染与硬皮病之间的关系。认为血清特异性抗体-Scl-70及抗着丝粒抗体检查是诊断或识别各型不典型硬皮病的重要方法。 This article reviews the various possible internal and external factors that cause scleroderma. The former has paraprotein deposition, diabetes, etc., which includes contact with silicon, vinyl chloride and certain drugs (bleomycin, penicillamine, analgesics and vitamin K). Describes the relationship between scleroderma after breast augmentation, tryptophan-induced eosinophilic myalgia syndrome, toxic oil syndrome, and spirochete infection and scleroderma. It is considered that the serum-specific antibody-Scl-70 and anti-centromere antibody test are important methods for diagnosis or identification of atypical scleroderma.