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该研究探讨了视皮层LTP由诱导期向维持期转化过程的突触形态学特征。实验选用18-30天龄的健康SD大鼠,分实验组、空白对照组及实验对照组进行电镜观测和图象分析。结果发现,在常规LTP实验程序中强直刺激后有LTP产生并记录80分钟的实验组脑片标片,局部有界面曲率大于2的较大U型突触形成,这种突触多有两个以上活性区。图象分析结果显示,实验组与对照组相比较,突触的界面曲率明显增大(P<0.05),活性区的长度明显加长(<0.05)。
This study explored the morphological features of synapses in the visual cortex LTP from the induction phase to the maintenance phase. The experiment selected 18-30 days old healthy SD rats, divided into experimental group, blank control group and experimental control group under electron microscope observation and image analysis. The results showed that in the conventional LTP experimental procedure LTP production after ankylosing spondylitis and record 80 minutes in the experimental group brain slices standard, the local interface curvature greater than 2 larger U-shaped synapses, this synapse more than two Above the active area. The results of image analysis showed that the curvature of the synaptic interface was significantly increased (P <0.05) and the length of the active region was significantly longer (P <0.05) compared with the control group.