论文部分内容阅读
目的研究妊娠早期妇女血清促甲状腺激素(TSH)和血压的关系。方法选取2008年8月至2010年3月在江苏省丰县妇幼保健院进行早孕确认的妊娠早期妇女305例,填写问卷,测量血压、身高、体重,空腹抽血测血清TSH,TSH异常者进一步测血清游离三碘甲状腺原氨酸(FT3)和游离甲状腺素(FT4),分析不同甲状腺功能状态组的收缩压(SBP)和舒张压(DBP)的特征,血清TSH与收缩压、舒张压的关系,比较各组高血压以及高血压前期的患病率和患病的危险性。结果 (1)亚临床甲状腺功能减退(亚临床甲减)组与甲状腺功能正常组(甲功正常组)相比,SBP、DBP差异无统计学意义。(2)不同血清TSH与收缩压和舒张压均无关。(3)亚临床甲减组高血压前期及高血压的总患病率高于甲功正常组(36.1%对29.8%),但差异无统计学意义(P>0.05)。经校正年龄、BMI后,妊娠早期亚临床甲减与高血压及高血压前期无独立相关(OR=1.399,95%CI 0.778~2.516,P=0.262)。结论妊娠早期TSH与孕妇血压无关,妊娠早期亚临床甲减与高血压及高血压前期无独立相关。
Objective To study the relationship between serum thyrotropin (TSH) and blood pressure in early pregnancy. Methods From August 2008 to March 2010, 305 pregnant women were enrolled in early pregnancy in Fengxian Maternal and Child Health Hospital of Jiangsu Province. The questionnaire was used to measure the blood pressure, height, weight, fasting blood serum TSH and TSH abnormalities Serum free triiodothyronine (FT3) and free thyroxine (FT4) were measured. The characteristics of systolic blood pressure (SBP) and diastolic blood pressure (DBP), serum TSH and systolic blood pressure and diastolic blood pressure The prevalence and risk of hypertension in each group were compared. Results (1) There was no significant difference in SBP and DBP between subclinical hypothyroidism (subclinical hypothyroidism) group and normal thyroid function group (normal thyroid function group). (2) Different serum TSH had no correlation with systolic and diastolic blood pressure. (3) The overall prevalence of prehypertension and hypertension in subclinical hypothyroidism group was higher than that in normal thyroid function group (36.1% vs 29.8%), but the difference was not statistically significant (P> 0.05). After adjustment for age, BMI, subclinical hypothyroidism in early pregnancy was not independently associated with hypertension and prehypertension (OR = 1.399, 95% CI 0.778-2.516, P = 0.262). Conclusion TSH in early pregnancy has nothing to do with blood pressure in pregnant women, and subclinical hypothyroidism in early pregnancy has no independent correlation with hypertension and prehypertension.