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由于克山病主要病变在心肌,所以用造成心肌缺氧缺血的条件来进行实验性心肌坏死的研究,近年来在克山病病因研究方面已进行了大量工作。自从北京军区卫生部报告克山病病区水中亚硝酸盐含量较高以来,曾有不少单位进行了用亚硝酸盐灌胃与病区粮两种复合因素以引起大白鼠心肌坏死的观察。1978年我们对四川省西昌地区18例死亡病人心肌进行几种酶组化观察,发现其中11例亚急型克山病人心肌坏死区周围组织细胞中有酸性磷酸酶活性升高的现象。Duve报导缺血性心肌溶酶体改变对心肌坏死起着重要作用。Ferrans曾根导用异丙基肾上腺素注射大鼠引起心肌细胞中溶酶体数目增加。我们采用亚硝酸钠灌胃,引起大鼠缺氧以观察心肌中两种酶的组织化学改
As Keshan disease is the main lesion in the myocardium, so with the condition of myocardial ischemia and hypoxia to experimental myocardial necrosis, in recent years in Keshan disease etiology has done a lot of work. Since the Ministry of Health of the Beijing Military Region reported that the water content of nitrite in Keshan disease area is high, many units have conducted the observation of two kinds of complex factors of nitrite gavage and ward-grain to cause myocardial necrosis in rats. In 1978, we detected 18 cases of cardiac death in Xichang, Sichuan Province, and found that there was an increase in acid phosphatase activity in the surrounding tissue cells in 11 cases of subacute Keshan disease. Duve reports that ischemic cardiac lysosomal changes play an important role in myocardial necrosis. Ferrans was induced by isoproterenol into rats to induce increased numbers of lysosomes in cardiomyocytes. We use sodium nitrite gavage, causing hypoxia in rats to observe the histochemistry of the two enzymes