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目的 :探讨大黄对大鼠腹腔感染致肺损伤防治作用的机制。方法 :采用大鼠盲肠结扎并穿孔 (CLP)造成腹腔感染 ,每天在麻醉下经胃管灌注大黄 1次。分别在术后 0 ,2 4 ,48,72 ,96 ,1 2 0h检测肺毛细血管通透性、肺组织的内毒素和肿瘤坏死因子 (TNF α) ,并取支气管肺泡灌洗液 (BALF)进行细胞学分析。结果 :肺毛细血管通透性、BALF的中性粒细胞百分率、肺组织的内毒素和TNF α逐渐增加 ,时间越长越明显 ,但药物组比感染组增加较慢、幅度较小。结论 :大黄可防止内毒素进入肺组织 ,抑制肺内中性粒细胞积聚 ,TNF α释放 ,减轻肺的炎性反应。
Objective: To explore the mechanism of rhubarb on the prevention and treatment of lung injury induced by abdominal infection in rats. Methods : Celiac ligated and perforated rats (CLP) were used to induce intraperitoneal infection. Rhubarb was infused through the stomach tube under anesthesia daily. Pulmonary capillary permeability, lung tissue endotoxin and tumor necrosis factor (TNF α) were measured at 0, 24, 48, 72, 96, and 120 hours after operation, and bronchoalveolar lavage fluid (BALF) was taken. Cytological analysis. RESULTS: Pulmonary capillary permeability, percentage of neutrophils in BALF, endotoxin and TNF α in lung tissue were gradually increased. The longer the time, the more obvious the drug was, but the drug group was slower and smaller than that of the infection group. Conclusion: Rhubarb can prevent endotoxin from entering lung tissue, inhibit the accumulation of neutrophils in the lung, release TNFα, and reduce the inflammatory response of the lung.