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本文报道以紫外分光光度法测定布洛芬含量，以氰酮为透皮吸收促进剂来考察布洛芬制剂的释放度，结果表明，布洛芬浓度在０．１～０．５μｇ／ｍｌ时与吸收度呈线性关系，氮酮含量在０％～２％时，在水包油（Ｏ／Ｗ）、油包水（Ｗ／Ｏ）型软膏及擦剂中的回收率依次为９３．２０％～１０１．５０％、９４．５４％～１００．１０％和９５．６０％～１００．２０％。从第３小时起，实验组的布洛芬透皮释放量比对照组高（Ｐ＜０．０５）．在Ｏ／Ｗ型软膏中，氮酮含量为０．５％～２．０％时，２４ｈ累积释放量Ｑ值为对照组的１．２９～４．６５倍，２％时最高；在Ｗ／Ｏ型软膏中，Ｑ值为对照组的１．１６～７．２５倍，２％时最高；在擦剂组中，氮酮含量为１％时，Ｑ值最高。
In this paper, the determination of ibuprofen content by UV spectrophotometry, cyanogen ketone as the transdermal absorption accelerator to explore the release of ibuprofen formulations, the results show that ibuprofen concentration of 0.1 ~ 0.5μg / ml And the absorbency showed a linear relationship. The recoveries of O / W, W / O ointment and liniment were 0 ~ 2% when the azone content was 0% ~ 2%. % ~ 101.50%, 94.54% ~ 100.10% and 95.60% ~ 100.20%. From the third hour onward, the transdermal delivery of ibuprofen in the experimental group was higher than that in the control group (P <0.05). In O / W type ointment, the Q value of accumulated release after 24h was 1.29 ~ 4.65 times of that of the control when the content of azone was 0.5% ~ 2.0%, the highest at 2% O ointment, the Q value of 1.16 ~ 7.25 times the control group, the highest 2%; in the liniment group, when the azone content of 1%, the highest Q value.