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大黄及其主要有效成分在临床和药理实验中被证实可治疗2型糖尿病、改善胰岛素抵抗,其作用通过多种信号通路调节胰岛素敏感性,包括作为PPARγ配体激活剂,抑制11β-1型羟基固醇脱氢酶,抑制胰岛素信号通路抑制蛋白PTP1B,和抑制脂肪组织间的低度炎症等。了解大黄的有效成分通过多种作用机制改善胰岛素抵抗,可为今后进一步研究中药多药效、多靶点的作用机制提供理论依据和思路。
Rhubarb and its major active ingredients have been shown clinically and pharmacologically to treat type 2 diabetes and improve insulin resistance. Its role in regulating insulin sensitivity through a variety of signaling pathways, including as a ligand activator of PPARγ, inhibits 11β-1 hydroxyl Sterol dehydrogenase, inhibit the insulin signal pathway inhibitor protein PTP1B, and inhibit low-grade inflammation between fatty tissues. To understand the active principle of rhubarb through a variety of mechanisms to improve insulin resistance can provide theoretical basis and train of thought for further study on the mechanism of multi-drug effect and multi-target of traditional Chinese medicine.