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目的探讨血清N末端B型钠尿肽原(NT-proBNP)在不明原因呼吸困难病因分析的临床意义。方法针对急诊入院不明原因呼吸困难的患者,应用电化学发光法检测患者血清NT-proBNP的浓度;详细追问病史、体格检查,结合心电图、心脏彩超、胸片、肺功能测定等相关检查,进一步明确患者呼吸困难的原因。结果心源性呼吸困难患者血清NT-proBNP浓度在829.20~18700.50 pg/ml间,NT-proBNP呈偏态分布,中位数水平分别为4474.80 pg/ml,非心源性呼吸困难患者血清NT-proBNP浓度在10.20~389.50 pg/ml间,NT-pro BNP呈偏态分布,中位数水平分别为174.20 pg/ml,两组患者血清NT-proBNP浓度中位数比较差异有统计学意义(P值<0.05)。结论血清NT-proBNP浓度在鉴别心源性或非心源性呼吸困难中有重要意义。
Objective To investigate the clinical significance of serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) in the etiological analysis of unexplained dyspnea. Methods For patients with unexplained dyspnea admitted to the hospital, the concentration of NT-proBNP in serum was detected by electrochemiluminescence. In detail, medical history, physical examination, combined with electrocardiogram, echocardiography, chest radiograph, lung function test and other related tests were further clarified Causes of dyspnea in patients. Results Serum NT-proBNP concentration was 829.20 ~ 18700.50 pg / ml in patients with cardiogenic dyspnea, NT-proBNP was skewed distribution, the median levels were 4474.80 pg / ml, NT-proBNP in patients with non-cardiac dyspnea NT- NT-pro BNP was skewed at a proBNP concentration of 10.20-389.50 pg / ml with a median of 174.20 pg / ml, respectively, and the median NT-proBNP concentration was significantly different between the two groups (P Value <0.05). Conclusion Serum NT-proBNP concentration is of great importance in the differential diagnosis of cardiogenic or non-cardiac dyspnea.