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心脏蒲肯野纤维是由蒲肯野细胞形成的纤维状网样结构,与房室束相连结,广泛分布于心内膜,在电冲动向心室肌的快速传播过程中起着重要的作用,使得左右心室快速同步激动。近年来的研究表明蒲肯野纤维好发心律失常,这主要是由于其解剖的复杂性和独特的细胞超微结构、电生理特性以及兴奋-收缩偶联的模式所导致的。蒲肯野纤维不仅可发生自律性和触发性心律失常,还可以发生折返性心律失常。无论是在结构性心脏病患者,还是在心脏结构正常的患者,蒲肯野纤维起源的触发灶经常可诱发心室颤动。另外,临床上许多单形性室性心动过速(室速)以蒲肯野纤维为折返环。对于蒲肯野纤维相关的单形性或多形性室性心律失常,以异常蒲肯野电位为靶点的导管消融往往十分有效。
Cardiac Purkinje fibers are fibrous mesh-like structures formed by Purkinje cells and are connected with the atrioventricular bundle and widely distributed in the endocardium, playing an important role in the rapid propagation of electrocardiogram to ventricular muscle. Make rapid synchronization of left and right ventricular activation. In recent years, studies have shown that the Purkinje fibers are prone to arrhythmia, which is mainly due to the complexity of their anatomy and the unique cell ultrastructure, electrophysiological properties and excited-contraction coupling mode. Purkinje fibers can not only occur self-regulatory and trigger arrhythmia, reentrant arrhythmias can occur. Triggers from Purkinje fibers often trigger ventricular fibrillation in both patients with structural heart disease and those with normal cardiac structures. In addition, many clinical monomorphic ventricular tachycardia (ventricular tachycardia) to Purkinje fiber as the annulus. Catheter ablation, which targets abnormal Purkinje potentials, is often effective with respect to Borken wild-fiber associated monomorphic or polymorphic ventricular arrhythmias.