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多毛症妇女常并发卵巢性雄激素过多症和肾上腺性雄激素过多症,特别是多囊卵巢妇女。下述假设可以解释这一现象。 (1)肾上腺性雄激素过多症引起促性腺激素分泌过多促发多囊卵巢形成。卵巢外组织的肾上腺雄激素转化为雌激素引起雌激素水平增高。(2)卵巢性雄激素分泌过多引起肾上腺部分缺乏导致肾上腺性雄激素过多;血浆催乳素增多可能为另一原因。多囊性卵巢妇女催乳素水平升高已有报道。血催乳素过高引起3-β-羟类固醇脱氢酶部分缺乏可能导致肾上腺性雄激素过多。实际上催乳素过多妇女硫酸脱氢表雄酮(S-DHA)和脱氢表雄酮(DHA)显著增多。
Hirsutism women often complicated by ovarian androgenic and adrenal hyperandrogenism, especially in women with polycystic ovary. The following assumptions explain this phenomenon. (1) Adrenal androgen hyperactivity caused by excessive secretion of gonadotropin to promote polycystic ovary formation. Overexpression of adrenal androgen into estrogen causes increased estrogen levels. (2) excessive ovarian androgen secretion caused by lack of part of the adrenal cause adrenal androgen excess; increased plasma prolactin may be another reason. Elevated levels of prolactin in polycystic ovarian women have been reported. Hyperprolactinmia caused by a partial lack of 3-β-hydroxysteroid dehydrogenase may lead to excessive adrenal androgen. In fact there is a significant increase in women with hyperprolactine S-DHA and DHA.