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目的:筛选复方咪康唑乳膏处方中最佳药物用量。方法:采用正交试验设计法,考察不同处方的复方咪康唑乳膏治疗豚鼠皮肤石膏样毛癣菌感染模型的作用和体外抑菌效果,根据考察数据设计最佳处方。结果:复方咪康唑乳膏的最佳处方为每1000 g乳膏中含氯霉素10 g,薄荷脑20 g,硝酸咪康唑20 g,月桂氮棹(?)酮30 g。结论:正交试验设计法优选复方咪康唑乳膏的配方,方法可行,收效满意。
Objective: To screen the optimal dosage of compound miconazole cream prescription. Methods: Orthogonal design method was used to study the effect of different prescriptions of miconazole cream on guinea pig plaster-like Trichophyton infection model in vitro and antibacterial effect in vitro. The best prescription was designed according to the data of observation. Results: The best prescription of compound miconazole cream was 1000g cream containing 10g of chloramphenicol, 20g of menthol, 20g of miconazole nitrate and 30g of laurocapram. Conclusion: Orthogonal test design method of compound miconazole cream formula, the method is feasible, with satisfactory results.