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目的评价米托蒽醌、阿糖胞苷(MA)方案作诱导治疗成人急性非淋巴细胞白血病(AN-LL)初治患者的疗效。方法采用米托嗯醌(mitoxantrone)和阿糖胞苷(cytarabine)对35例成人ANLL患者进行联合化疗。结果临床和血液学完全缓解(CR)15例(42.9%),部分缓解(PR)9例(25.7%),总有效率68.6%。结论在强力支持治疗的基础上,MA方案治疗成人难治性急性非淋巴细胞白血病有较好的疗效,其毒副作用可以耐受。
Objective To evaluate the efficacy of mitoxantrone and cytarabine (MA) regimen in the induction of initial treatment of adult patients with acute non-lymphocytic leukemia (AN-LL). Methods 35 adult ANLL patients were treated with mitoxantrone and cytarabine. Results Clinical and hematological complete remission (CR) in 15 cases (42.9%), partial remission (PR) in 9 cases (25.7%), the total effective rate 68.6%. Conclusions On the basis of strong supportive therapy, MA regimen has a good curative effect in the treatment of adult refractory acute non-lymphocytic leukemia and its toxic side effects can be tolerated.