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目的研究慢性阻塞性肺疾病(COPD)患者合并肺性脑病时进行纳洛酮联合无创正压机械通气(NIPPV)治疗的效果。方法将2009年1月—2011年3月我院收治的60例COPD合并肺性脑病患者随机分为治疗组30例和对照组30例。治疗组采用常规治疗及纳洛酮联用NIPPV,对照组采用常规治疗及NIPPV,观察两组的治疗效果。结果两组患者治疗效果存在显著差异,与对照组比较,治疗组血气分析改善明显,意识障碍恢复快,气管插管率明显降低,平均住ICU时间明显减少。结论对于COPD合并肺性脑病患者,纳洛酮联用NIPPV是一种有效的治疗方法。
Objective To investigate the effect of naloxone combined with noninvasive positive pressure mechanical ventilation (NIPPV) in patients with chronic obstructive pulmonary disease (COPD) complicated with pulmonary encephalopathy. Methods From January 2009 to March 2011, 60 patients with COPD and pulmonary encephalopathy admitted to our hospital were randomly divided into treatment group (30 cases) and control group (30 cases). The treatment group was treated with conventional therapy and naloxone combined with NIPPV, while the control group was treated with conventional therapy and NIPPV. The therapeutic effect was observed in both groups. Results There was a significant difference in therapeutic effect between the two groups. Compared with the control group, the blood gas analysis in the treatment group improved obviously, the disturbance of consciousness was recovered, the tracheal intubation rate was significantly reduced, and the average ICU time was significantly reduced. Conclusion Naloxone combined with NIPPV is an effective treatment for COPD patients with pulmonary encephalopathy.