目前认为新生儿溶血性疾病是母亲体内扰胎儿红细胞的IgG抗体被动输入胎儿所致。母体抗胚胎HLA抗原的抗体是否能使新生儿产生血小板减少尚不清楚。Kelton等曾报道两例新生儿血小板减少症,可能由于抗HLA抗体引起。本文作者对此也进行了近两年的研究。将1507名产妇血清进行HLA抗体检查分类,对在此研究期间出生的新生儿,出生后一周内都进行了是否出现自发性内出血的观察,对怀疑出血的病例进行了血球、血小板计数,血清胆红素检查和微量细胞毒试验。 1507名妇女中,495人(32.8％)的血 At present, the newborn hemolytic disease is that mothers fetus fetus red blood cells IgG antibody passive input due to the fetus. It is unclear whether the maternal anti-embryonic HLA antigens can cause thrombocytopenia in newborns. Kelton et al reported two cases of neonatal thrombocytopenia, may be due to anti-HLA antibodies. The author of this article also conducted the research for the past two years. 1507 maternal serums were tested for HLA antibody. Neonates born during the study period were observed for spontaneous internal bleeding within a week after birth. Blood samples, platelet counts, serum gallbladder count Red check and trace cytotoxicity test. Among 1507 women, 495 (32.8%) had blood