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目的探讨2型糖尿病人群血清瘦素水平与胰岛素抵抗的关系。方法2001-102002-08对河北医科大学第三医院的196例受试者(2型糖尿病者118例、对照者78名)用放射免疫法测定空腹血清瘦素水平,同时测量身高、体重、腰围、臀围。结果糖化血红蛋白(HbA1c)、收缩压(SBP)、甘油三酯(TG)和瘦素(Leptin)是影响胰岛素敏感性的因素;2型糖尿病组瘦素质量浓度高于对照组;肥胖者瘦素质量浓度显著升高,而2型糖尿病组内肥胖与非肥胖者之间瘦素质量浓度差异无显著性。结论肥胖者大多存在胰岛素抵抗;2型糖尿病人无论肥胖与否均存在一定程度的胰岛素抵抗。
Objective To investigate the relationship between serum leptin level and insulin resistance in type 2 diabetic patients. Methods: The fasting serum leptin level was measured by radioimmunoassay in 196 subjects (118 cases of type 2 diabetes mellitus and 78 controls) in the Third Hospital of Hebei Medical University from 2001 to 2002. The levels of body weight, waist circumference Hip. Results HbA1c, SBP, TG and Leptin were the factors influencing insulin sensitivity. The leptin concentration in type 2 diabetes mellitus group was higher than that in control group. The obesity leptin There was no significant difference in the concentration of leptin between obese and non-obese patients in type 2 diabetes group. Conclusion Most obese patients have insulin resistance. Type 2 diabetes patients have some degree of insulin resistance whether obese or not.