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目的分析起搏器植入患者预防性应用抗菌药物的情况及存在的问题。方法对我院2006年1月至2011年12月的116例起搏器植入患者预防性应用抗菌药物的情况进行调查分析。结果 116例患者抗菌药物使用率为100%,药物共计5个大类14个品种,其中使用频度最高的3个品种依次是头孢噻吩、哌拉西林和头孢替安;主要是单联用药(102例),二联用药有2例,单联更换用药有12例。86例患者用量超过说明书规定,114例患者预防给药时机不合理,术后用药时间(4.6±2.8)d,使用最长的20 d,最短2 d。结论在我院起搏器植入患者中,抗菌药物选择的起点较低,联合用药较少,但单次给药的剂量过大,预防给药的时机不合理,术后用药时间较长,需要进一步加强抗菌药物规范化使用的管理。
Objective To analyze the situation and existing problems of prophylactic use of antibacterials in patients undergoing pacemaker implantation. Methods A total of 116 patients with pacemaker implanted in our hospital from January 2006 to December 2011 were investigated for their prophylactic use of antimicrobial agents. Results Among the 116 patients, the antibacterial drug use rate was 100%, and the drugs were in 5 categories and 14 varieties in total. Among them, the three most frequently used varieties were cefalothin, piperacillin and cefotiam; 102 cases), two cases of medication in 2 cases, single replacement medication in 12 cases. The dosage of 86 patients surpassed the specification, and the timing of prophylaxis in 114 patients was unreasonable. The duration of postoperative medication was 4.6 ± 2.8 days, the longest use was 20 days and the shortest was 2 days. Conclusions In the patients with pacemaker implanted in our hospital, the starting point for the selection of antimicrobial agents is low, the combination of medication is less, but the dose of a single administration is too large, the timing of prevention of medication is unreasonable, the medication time is longer, Need to further strengthen the standardized use of antimicrobial management.