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近几年美国和加拿大AIDS及其相关性恶性肿瘤的发生率均有下降,这种趋势反映了八十年代早期以后感染率的下降和联合抗病毒治疗的效果,但是没有资料显示AIDS相关性恶性肿瘤的发生与AIDS感染率的下降或抗病毒治疗的关系。本研究对622例HIV阳性的男性同性恋患者进行了前瞻性追踪研究,并用Cox比例风险模型进行统计分析,发现其中421例(68％)1981年前抗HIV抗体已阳性,到1996年底之前,有182例诊断为Kaposis’s肉瘤(KS),48例诊断为淋巴瘤,KS的发生率1993～1995年为每年3.5％,1996年降为0,
In recent years, the incidence of AIDS and its associated malignancies has dropped in both the United States and Canada, a trend that reflects the decline in infection rates and combined antiviral treatment since the early 1980s, but no data have been shown for AIDS-related malignancy The incidence of cancer and the decline in the rate of AIDS infection or the relationship between anti-virus treatment. In our study, 622 HIV-positive gay men with HIV were prospectively studied and statistically analyzed with the Cox proportional hazards model. Of these, 421 (68%) had positive anti-HIV antibodies prior to 1981 and by the end of 1996 had 182 cases were diagnosed as Kaposis’s sarcoma (KS), 48 cases were diagnosed as lymphoma. The incidence of KS was 3.5% in 1993-1995 and 0 in 1996,