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目的:探讨血清学标志物S100B联合NSE检测在足月新生儿HIE疾病的早期诊断和监测中的价值,为临床诊治提供更多补充性依据。方法:以2009年7月～2011年7月收治的236例足月新生儿HIE患者为研究对象,选择同期出生的236例足月健康新生儿为对照组,应用电化学发光法监测HIE患者病程早期(入组后第1天、第3～5天,第7～10天)的血清S100B和NSE水平。结果:HIE组血清S100B和NSE水平显著高于对照组,各观察点P<0.05;第3～5天除轻度组外,S100B和NSE分别在重度组、中度组和重度组有显著性上升,均P<0.05。治疗前后(第7～10天对比第1天)S100B和NSE在各组均有显著性降低,P<0.05;轻度组在初步治疗后S100B和NSE基本上能恢复正常,与健康对照组无显著性差异,P>0.05,其他组仍然显著高于对照组,P<0.05;S100B和NSE相关性较好,r=0.950,P>0.05。结论:血清S100B和NSE联合检测是足月新生儿HIE疾病早期监测和辅助诊断的合理模式,有助于为临床诊治提供更多补充性证据。
Objective: To investigate the value of serological marker S100B combined with NSE in the early diagnosis and monitoring of full-term neonatal HIE and to provide more supplementary evidence for clinical diagnosis and treatment. Methods: Totally 236 full-term newborns with HIE admitted to our hospital from July 2009 to July 2011 were enrolled in this study. 236 full-term healthy newborns were selected as control group. The duration of HIE patients was monitored by electrochemiluminescence Serum levels of S100B and NSE were early (day 1, day 3 to day 5, day 7 to day 10 after enrollment). Results: The levels of serum S100B and NSE in HIE group were significantly higher than those in control group (P <0.05). The levels of S100B and NSE in severe group, moderate group and severe group were significantly lower than those in mild group Rise, all P <0.05. The levels of S100B and NSE in all groups were significantly decreased before and after treatment (days 7-10), P <0.05; while in mild group, S100B and NSE basically returned to normal after initial treatment, Significant differences, P> 0.05, the other groups were still significantly higher than the control group, P <0.05; S100B and NSE correlation was good, r = 0.950, P> 0.05. Conclusion: The combination of serum S100B and NSE is a reasonable model for the early monitoring and diagnosis of HIE in term neonates, which will be helpful to provide more supplementary evidence for clinical diagnosis and treatment.