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Sorensen(1939)首先在牛乳中发现一种橙红色的含铁蛋白质,Schafer(1951)在人乳中也发现了类似的含铁蛋白质,Masson(1966)发现这种人乳中的含铁蛋白质也存在于人的唾液、鼻腔分泌物、泪液、支气管粘液、胆汁、胰液、精液、宫颈粘液和尿中。尔后,在中性粒细胞和血浆中也见到这种蛋白质。最初发现于牛乳中,故曾称作牛乳蛋白、乳铁素(lactosiderophilin)或乳酸转铁蛋白(lactotransferrin)。目前,一般称作乳铁蛋白(lactoferrin,简称LF)。Groves(1960)用酸提取法提纯了LF,并对其理化性质进行了初步的阐述。从此,LF的理化性质、分子结构和分布代谢等才有了进一步的研究和了解。
Sorensen (1939) first found an orange-red ferritin in milk. Schafer (1951) also found similar ferritin in human milk. Masson (1966) found that ferritin in human milk is also In human saliva, nasal secretions, tears, bronchial mucus, bile, pancreatic juice, semen, cervical mucus and urine. Later, in neutrophils and plasma also see this protein. Originally found in milk, it was once called milk protein, lactosiderophilin or lactotransferrin. Currently, it is commonly called lactoferrin (LF). Groves (1960) purified LF by acid extraction and described its physical and chemical properties. Since then, the physical and chemical properties of LF, molecular structure and distribution of metabolism have further study and understanding.