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以取代苯胺为起始原料,经重氮化、叠氮钠取代制得取代叠氮苯,然后在碱性条件下和乙酰乙酸乙酯脱水合环,生成取代三唑酸,再与二氯亚砜反应得到酰氯,酰氯与碳酸铵研磨得酰胺。该方法反应产物单一,产率高,且避免了催化剂的使用,成本较低,反应周期短,效率较高,对环境友好,这为5-甲基-1-芳基-1,2,3-三唑-4-甲酸酰胺的合成提供了一种简便有效的方法。
Substituted aniline as a starting material, the diazotization, sodium azide substituted substituted azide benzene, and then under the alkaline conditions and ethyl acetoacetate dehydration ring, the generation of substituted triazole acid, and then dichloro The sulfone reaction gives the acid chloride, which is triturated with ammonium carbonate to give the amide. The method has the advantages of single reaction product, high yield, avoided the use of catalyst, low cost, short reaction period, high efficiency and environment friendliness, which is 5-methyl-1-aryl-1,2,3 - triazole-4-carboxylic acid amide provides a simple and efficient method.