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将109例高血压病患者随机分为两组,中药组用90大圣降压口服液,对照组用硝苯吡啶。结果:中药组临床有效率与降压作用与对照组比较均无显著性差异(P均>0.05);但中药组在改善微循环、降低动脉硬化指数方面有效,且在降低血脂、提高高密度脂蛋白(HDL)方面,明显优于对照组(P<0.05)。实验研究表明:中药组能有效地降低易卒中自发性高血压大白鼠(SHRSP)的血压,提高小鼠耐缺氧的能力。临床和毒理试验均证实90大圣降压口服液无毒性、无副作用,为该药用于预防和治疗高血压病提供了客观依据。
109 patients with hypertension were randomly divided into two groups. The Chinese medicine group used 90 Da Sheng Jiang Oral Liquid and the control group used nifedipine. Results: There was no significant difference in clinical efficacy and antihypertensive effect between the TCM group and the control group (P>0.05). However, the TCM group was effective in improving microcirculation and reducing the atherosclerosis index, and in reducing blood lipids and improving High-density lipoprotein (HDL) was significantly better than the control group (P<0.05). Experimental studies have shown that: Chinese medicine group can effectively reduce the blood pressure of stroke-prone spontaneously hypertensive rats (SHRSP) and improve the ability of mice to withstand hypoxia. Both clinical and toxicological tests have confirmed that 90 Da Sheng Qi Oral Liquid is non-toxic and has no side effects, which provides an objective basis for the prevention and treatment of hypertension.