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为研究ABO血型不合对Allo PBSCT患者造血重建的影响 ,将 2 0例恶性血液病(CML 9例、ALL 8例、难治性NHL 3例 )按统计学配对原则分组 ,ABO血型异同者各 10例 ,两组年龄、性别、诊断、移植前病程、疾病状态、预处理方案、输注的MNC和CD34+ 细胞量及GVHD预防方法均无明显差异(P >0 0 5 )。外周血干细胞经G CSF动员后CS 30 0 0Plus分离 ,移植后定期检查血象和血型抗体滴度。结果显示 ,血型转为供者型的中位数时间 (40 2± 2 5 )天 ,白细胞、血小板达正常水平在两组中无明显差异 (P >0 0 5 ) ,而血红蛋白 <110g/L者在ABO血型不合组明显高于ABO血型相合组 (5 5 %∶2 5 % ,P <0 0 1)。 6例ABO血型主要不合者 3例发生纯红再障。提示供受者ABO血型不合影响红系造血重建 ,主要血型抗原不合时容易发生纯红再障 ,而GVHD及移植相关死亡率与红细胞血型无关
To investigate the effect of ABO incompatibility on the hematopoietic reconstitution in patients with Allo PBSCT, 20 patients with hematologic malignancies (9 CML, 8 ALL and 3 refractory NHL) were grouped according to statistical matching principle. For example, there were no significant differences in age, gender, diagnosis, pre-transplant duration, disease status, pretreatment regimen, amount of MNC and CD34 + infused cells, and prevention of GVHD (P> 0.05). Peripheral blood stem cells were isolated by CS 30 mobilization after G CSF mobilization, and blood samples and blood group antibody titers were checked regularly after transplantation. The results showed that there was no significant difference between the two groups (P> 0.05), while the hemoglobin level was less than 110g / L The ABO blood group incompatibility was significantly higher than that of ABO blood group (5 5%: 25%, P 0 01). 6 cases of ABO blood group mainly in 3 cases of pure red aplasia. Suggesting that donor ABO blood group incompatibility with erythrocytic hematopoietic reconstructions, the main blood group antigen prone to pure red aplastic anemia, and GVHD and graft-related mortality has nothing to do with the red blood cell type