论文部分内容阅读
研究了大鼠 W_(256)肿瘤组织中前列腺素(PGE_2)的含量与正常组织的关系,并观察药物对 PGE_2含量的影响.实验结果表明。肺和胃肠中 PGE_2含量较高,肝和肿瘤组织中含量较低.足叶乙甙(VP_(16-213))腹腔注射20 mg/kg,能明显提高 W_(256)大鼠肝组织中 PGE_2的含量;三尖杉酯碱腹腔注射1 mg/kg 能明显降低瘤组织中 PGE_2的含量;血卟啉衍生物 HPD 和去甲斑蟊素对 PGE_2含量无明显影响.
The relationship between prostaglandin (PGE 2) content and normal tissue in rat W (256) tumor tissue was studied, and the effect of drugs on PGE 2 content was also observed. The contents of PGE_2 in lung and gastrointestinal tract were higher than those in liver and tumor tissues, and the intraperitoneal injection of 20 mg / kg etoposide (VP_ (16-213)) significantly increased the content of PGE_2 PGE_2 content; intraperitoneal injection of harringtonine 1 mg / kg can significantly reduce the content of PGE_2 in tumor tissue; hematoporphyrin derivatives HPD and norcantharidin on PGE_2 content was not significantly affected.