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目的：为研究5-氟尿嘧啶（5－Fluorouracil,5－FU）联合眼球按摩在小梁切除术后防治瘢痕形成中的作用。方法：将54例（54只眼）小梁切除术后眼压失控的青光眼随机分5－FU联合眼球按摩组34只眼和对照组20只眼，5－FU联合眼球按摩组术后结膜下注射5－FU5mg并行眼球按摩2～3分钟。对照组Ⅰ10只眼术后结膜下注射5－FU5mg，对照组Ⅱ10只眼行眼球按摩。追踪观察10个月～3年，平均2年。结果：5－FU联合眼球按摩组术前平均眼压为4．54kPa（1kPa=7．5mmHg），术后平均眼压为2．23kPa，成功率为97％。对照组Ⅰ术前平均眼压为4．43kPa，术后平均眼压为3．43kPa，成功率为60％，对照组Ⅱ术前平均眼压为4．34kPa，术后平均眼压为4．04kPa，成功率为50％，P＜0．0001。治疗组2只眼出现角膜混浊，1只眼出现低限压。对照组未见角膜损害及伤口渗漏。结论：5－FU联合眼球按摩在青光眼小梁切除术后能起到防治瘢痕形成的作用。
Objective: To study the effect of 5-fluorouracil (5-FU) combined with ocular massage on the prevention and treatment of scars after trabeculectomy. Methods: Fifty-four eyes (54 eyes) of glaucoma with uncontrollable intraocular pressure after trabeculectomy were randomly divided into 5 eyes (34 eyes) and 20 eyes (20 eyes) of control group, and 5-FU combined with ocular massage group Injection 5-FU5mg parallel eye massage 2 to 3 minutes. In the control group, 10 eyes received subconjunctival injection of 5-FU 5 mg and the control group II10 eyes underwent eyeball massage. Follow-up observation of 10 months to 3 years, an average of 2 years. Results: The preoperative average intraocular pressure was 4.54kPa (1kPa = 7.5mmHg) in 5-FU combined with ocular massage. The mean intraocular pressure was 2.23kPa and the success rate was 97%. The average preoperative intraocular pressure was 4.43kPa in control group, the average postoperative intraocular pressure was 3.43kPa, the success rate was 60%. The average preoperative intraocular pressure was 4.34kPa in control group Ⅱ, and the average intraocular pressure was 4 after operation. 04kPa, the success rate was 50%, P <0.0001. In the treatment group, corneal opacity occurred in 2 eyes and low pressure was observed in 1 eye. No corneal damage and wound leakage in the control group. Conclusion: 5-FU combined with ocular massage can prevent and treat scar formation after trabeculectomy in glaucoma.