生物钟BMAL1基因编码一种bHLH/PAS结构域转录因子家族蛋白质,是分子昼夜震荡器的关键元件,对于哺乳动物昼夜节律的产生是必需的。近年来的研究发现,BMAL1基因不仅在调控生物的昼夜节律中发挥一定作用,而且在脂肪细胞的增殖和分化、糖代谢、能量平衡方面起着关键作用。这些研究结果为BMAL1基因与脂肪代谢以及肥胖之间的联系提供了支持。 The Biological Clock The BMAL1 gene encodes a family of bHLH / PAS domain transcription factor proteins that are key elements of the circadian oscillator of molecules and are essential for the generation of mammalian circadian rhythms. In recent years, the study found that BMAL1 gene not only plays a role in regulating circadian rhythms of organisms, but also plays a key role in the proliferation and differentiation of adipocytes, glucose metabolism and energy balance. These findings provide support for the link between the BMAL1 gene and fat metabolism and obesity.